Alex Infascelli was born in Rome. At the age of 21 he moved to Los Angeles to pursue his musical career. He collaborated with several directors including David Fincher, Dominic Sena, Rebecca Blake, Mark Romanek and Mark Pellington. He then returned home to start his directing career. In two years he became one of Italy's most sought after music video director. He collaborated with Bernardo Bertolucci, directing a video for "Lucy" by The Cocteau Twins for the "Stealing Beauty" soundtrack. In 1995 he directed a short film, part of the feature film "De Gegerazione" directed by several other debuting directors, including Asia Argento. In 1996 he took part in another episodic feature film called "Esercizi Di Stile" also directed by household names such as Dino Risi, Mario Monnicelli and Sergio Citti. The year 2000 marked his debut in feature films with "Almost Blue"( "David di Donatello", "Nastro D'Argento" and "Ciak d'Oro" awards).
His second feature "The Vanity Serum" was released in 2004 and selected for the Sao Paulo International Film Festival, the Brussels Fantasy Film Festival and Pifan in Puchon, Korea. In 2006 he produced and directed Hate2o. In 2008 he directed the first original production by SKY in Italy: a two parts feature film based on a late 90's famous satanic killings case in northern Italy (Tv Best Director award,). In 2012 he co-founded Kinethica and is currently working on the adaptation of the book 'Stanley Kubrick And Me'. Infascelli also works as a photographer and journalist for Vanity Fair and Rolling Stone and has been a a permanent jury member for the Italian Cinema Academy – David di Donatello since 2001.